Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970500 | 0.96 | HSD11B1 (0.44) | HSD11B1EPHX2ROCK1KMT2ATRPV4 | |
| SCHEMBL4964824 | 0.88 | EPHX2 (0.49) | EPHX2ROCK1TRPV4ALDH1A1 | |
| SCHEMBL4966984 | 0.88 | HDAC3 (0.48) | EPHX2ROCK1HDAC3HDAC4HDAC1 | |
| SCHEMBL4969661 | 0.86 | HSD11B1 (0.44) | HSD11B1EPHX2ROCK1KMT2ATRPV4 | |
| SCHEMBL4962582 | 0.85 | HSD11B1 (0.41) | HSD11B1EPHX2KMT2ATRPV4ALDH1A1 | |
| SCHEMBL4964132 | 0.83 | ROCK1 (0.42) | EPHX2ROCK1TRPV4HRH3MAPK1 | |
| SCHEMBL4965287 | 0.82 | HSD11B1 (0.44) | HSD11B1EPHX2ROCK1KMT2ATRPV4 | |
| SCHEMBL4967467 | 0.82 | KMT2A (0.42) | KMT2AALDH1A1 | |
| SCHEMBL4962933 | 0.81 | KMO (0.43) | HSD11B1EPHX2KMT2AALDH1A1HTR2A | |
| SCHEMBL4965583 | 0.79 | NPC1 (0.43) | HSD11B1ROCK1KMT2ATRPV4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |