Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967201 | 0.84 | TSHR (0.37) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL13321613 | 0.82 | FLT1 (0.38) | TSHRHTTMEN1CYP3A4HPGD | |
| SCHEMBL28746076 | 0.82 | HTT (0.38) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL2560634 | 0.79 | NOS3 (0.44) | TSHRHTTMEN1CYP3A4HPGD | |
| SCHEMBL15740391 | 0.79 | NOS3 (0.42) | TSHRHTTMAPTNOS3NOS1 | |
| SCHEMBL15747320 | 0.79 | PTGES2 (0.41) | CA12CA1CA2CA9NOS3 | |
| SCHEMBL27600768 | 0.79 | IDO1 (0.47) | MEN1CYP3A4HPGDALOX15KMT2A | |
| SCHEMBL4967989 | 0.78 | PKM (0.34) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL4968002 | 0.78 | PSEN1 (0.36) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL4706651 | 0.77 | IDO1 (0.46) | MEN1CYP3A4HPGDALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220204498-A1 | PYRIDO-PYRIMIDINYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2022-06-30 | — | — | US | disclosed |
| CN-113795307-A | Pyridopyrimidinyl compounds and methods of use thereof | 基因泰克公司 | 2021-12-14 | — | — | CN | disclosed |
| US-20080171737-A1 | CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-07-17 | — | — | US | disclosed |
| WO-2008073956-A2 | CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171737-A1 | CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | SLC6A4, SLC6A2, SLC6A3 | TSHR 3614/4885CA12 590/4885CA1 468/4885 |
| US-20220204498-A1 | PYRIDO-PYRIMIDINYL COMPOUNDS AND METHODS OF USE | XBP1, HSPA5, ERN2 | TSHR 2970/4885CA12 4868/4885CA1 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.