SCHEMBL4965452

SCHEMBL4965452

Nc1cccc(Oc2cccc(N)c2-c2ccccc2)c1-c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
HSD17B10 Q99714 2/20 0.43
TDP1 Q9NUW8 2/20 0.41
ADRA2B P18089 1/20 0.41
PTGS1 P23219 1/20 0.41
MAPT P10636 2/20 0.41
KDM4E B2RXH2 1/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
GAA P10253 2/20 0.39
BRD4 O60885 1/20 0.38
MAPK1 P28482 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CYP3A4 P08684 2/20 0.38
ALOX15 P16050 1/20 0.38
CASP1 P29466 1/20 0.38
CASP7 P55210 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25135312 0.96 KDM4E (0.47) ALDH1A1HSD17B10TDP1ADRA2BPTGS1
SCHEMBL3789240 0.90 NCOA1 (0.49) ALDH1A1HSD17B10NCOA1NCOA3GAA
SCHEMBL25135315 0.85 NCOA1 (0.62) ALDH1A1HSD17B10TDP1MAPTNCOA1
SCHEMBL3789398 0.83 ALDH1A1 (0.59) ALDH1A1HSD17B10TDP1ADRA2BPTGS1
SCHEMBL25135310 0.82 MAOB (0.58) ALDH1A1MAPTNCOA1NCOA3GAA
SCHEMBL3800513 0.81 NCOA1 (0.53) ALDH1A1HSD17B10TDP1MAPTNCOA1
SCHEMBL5754263 0.81 ALDH1A1 (0.55) ALDH1A1HSD17B10TDP1MAPTBRD4
SCHEMBL7731922 0.79 ALDH1A1 (0.39) ALDH1A1HSD17B10TDP1ADRA2BPTGS1
SCHEMBL3793754 0.79 ALDH1A1 (0.63) ALDH1A1HSD17B10TDP1ADRA2BPTGS1
SCHEMBL3789550 0.79 MAOB (0.53) ALDH1A1MAPTKDM4ENCOA1NCOA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103038323-B Containing the lubricating composition of amine-functionalized additive THE LUBRIZOL CORP. (US) 2015-09-16 CN disclosed
CN-102292422-B Lubricating composition containing carboxylic acid and aromatic polyamine functionalized polymer LUBRIZOL CORP 2014-12-24 CN disclosed
EP-1321487-B1 POLYAMIC ACID, POLYIMIDE, PROCESS FOR PRODUCING THESE, AND FILM OF THE POLYIMIDE MITSUI CHEMICALS INC (JP) 2008-02-27 EP disclosed
US-6734276-B2 RANDOM COPOLYMER WITH UNITS DERIVED FROM PYROMELLITIC ACID, P-PHENYLENEDIAMINE, AND AT LEAST ONE OF M-PHENYLENEDIAMINE, BIS(P-AMINOPHENYL) ETHER, AND DIAMINOMETHYLNORBORNANE; LINEAR EXPANSION COEFFICIENT; SHRINKAGE INHIBITION MITSUI CHEMICALS, INC. (JP) 2004-05-11 US disclosed
US-6710160-B2 VARNISH HAVING IMPROVED SMOOTHNESS, THERMAL RESISTANCE, MELT FLOWABILITY, OPTICAL PROPERTIES AND CHEMICAL RESISTANCE; DIELECTRICS MITSUI CHEMICALS, INC. (JP) 2004-03-23 US disclosed
EP-1321487-A1 POLYAMIC ACID, POLYIMIDE, PROCESS FOR PRODUCING THESE, AND FILM OF THE POLYIMIDE Mitsui Chemicals, Inc. (JP) 2003-06-25 EP disclosed
US-20030013838-A1 Novel polyimide and circuit substrate comprising the same MITSUI CHEMICALS, INC. (JP) 2003-01-16 US disclosed
US-20020188090-A1 Polyamic acid, polyimide, process for producing these, and film of the polyimide MITSUI CHEMICALS, INC. (JP) 2002-12-12 US disclosed
EP-1236756-A1 NOVEL POLYIMIDE AND CIRCUIT SUBSTRATE COMPRISING THE SAME Mitsui Chemicals, Inc. (JP) 2002-09-04 EP disclosed