Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD1 | O95696 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608648 | 0.80 | KMT2A (0.49) | KMT2AMEN1POLBALDH1A1HSD11B1 | |
| SCHEMBL4963075 | 0.78 | HSD11B1 (0.61) | KMT2AMEN1POLBALDH1A1HSD11B1 | |
| SCHEMBL4963016 | 0.76 | HSD11B1 (0.61) | KMT2AMEN1POLBALDH1A1HSD11B1 | |
| SCHEMBL3625053 | 0.74 | HSD11B1 (0.61) | KMT2AMEN1POLBALDH1A1HSD11B1 | |
| SCHEMBL4968167 | 0.74 | ROCK1 (0.41) | ALDH1A1 | |
| SCHEMBL4964152 | 0.73 | CA1 (0.40) | KMT2AMEN1POLBCA1CA2 | |
| SCHEMBL4967012 | 0.70 | HSD11B1 (0.58) | KMT2AMEN1POLBHSD11B1HSD17B1 | |
| SCHEMBL7140715 | 0.69 | KMT2A (0.46) | KMT2AMEN1POLBALDH1A1HSD11B1 | |
| SCHEMBL27650013 | 0.69 | KMT2A (0.63) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3622234 | 0.68 | KMT2A (0.45) | KMT2AMEN1POLBALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |