Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 18/20 | 0.57 |
| ▸ | HRH1 | P35367 | 13/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966171 | 0.82 | CCR3 (0.55) | CCR3HRH1KCNH2MAPT | |
| SCHEMBL4968189 | 0.81 | CCR3 (0.51) | CCR3HRH1KCNH2 | |
| SCHEMBL4965938 | 0.78 | CCR3 (0.71) | CCR3HRH1KCNH2 | |
| SCHEMBL4967114 | 0.73 | HRH1 (0.83) | CCR3HRH1KCNH2 | |
| SCHEMBL4965732 | 0.73 | CCR3 (0.57) | CCR3HRH1KCNH2MAPT | |
| SCHEMBL4967412 | 0.73 | CCR3 (0.55) | CCR3HRH1KCNH2MAPT | |
| SCHEMBL4970161 | 0.72 | HRH1 (1.00) | CCR3HRH1KCNH2 | |
| SCHEMBL4969395 | 0.72 | LIPG (0.57) | CCR3MAPT | |
| SCHEMBL4969175 | 0.72 | MAPT (0.53) | CCR3HRH1KCNH2MAPT | |
| SCHEMBL24076616 | 0.70 | NPFFR1 (0.53) | CCR3NPFFR1NPFFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |