Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CCR3 | P51677 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LPL | P06858 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966171 | 0.90 | CCR3 (0.55) | MAPTHRH1CCR3KCNH2LPL | |
| SCHEMBL4969473 | 0.81 | HRH1 (0.57) | HRH1CCR3KCNH2 | |
| SCHEMBL4969395 | 0.80 | LIPG (0.57) | MAPTCCR3LPLLIPGSIGMAR1 | |
| SCHEMBL4965105 | 0.79 | CCR3 (0.49) | CCR3LPLLIPGOPRM1 | |
| SCHEMBL4966936 | 0.77 | HRH1 (0.64) | HRH1CCR3KCNH2 | |
| SCHEMBL4967383 | 0.77 | HRH1 (0.68) | HRH1CCR3KCNH2 | |
| SCHEMBL4969428 | 0.75 | SIGMAR1 (0.50) | HRH1CCR3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL4966840 | 0.75 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL4967412 | 0.74 | CCR3 (0.55) | MAPTHRH1CCR3KCNH2LPL | |
| SCHEMBL4969463 | 0.74 | HRH1 (0.63) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |