Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 13/20 | 0.51 |
| ▸ | HRH1 | P35367 | 12/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969428 | 0.90 | SIGMAR1 (0.50) | CCR3HRH1KCNH2HTR1ASIGMAR1 | |
| SCHEMBL4970299 | 0.87 | CCR3 (0.52) | CCR3HTR1ASIGMAR1CYP2C9CYP2C19 | |
| SCHEMBL4968718 | 0.81 | HRH1 (0.62) | CCR3HRH1KCNH2 | |
| SCHEMBL4965723 | 0.81 | CCR3 (0.57) | CCR3HRH1KCNH2 | |
| SCHEMBL4969159 | 0.78 | HRH1 (0.57) | CCR3HRH1KCNH2 | |
| SCHEMBL4966171 | 0.77 | CCR3 (0.55) | CCR3HRH1KCNH2CCR2 | |
| SCHEMBL4965938 | 0.77 | CCR3 (0.71) | CCR3HRH1KCNH2MEN1KMT2A | |
| SCHEMBL4968548 | 0.76 | HRH1 (0.58) | CCR3HRH1KCNH2 | |
| SCHEMBL4965732 | 0.73 | CCR3 (0.57) | CCR3HRH1KCNH2 | |
| SCHEMBL4969071 | 0.71 | HRH1 (0.66) | CCR3HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |