Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CCR4 | P51679 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969440 | 0.86 | HCRTR1 (0.47) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4962685 | 0.80 | MEN1 (0.60) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4963696 | 0.79 | CCR2 (0.43) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4963934 | 0.79 | HSD11B1 (0.49) | CCR4HSD17B1HSD11B1HSD17B2KDM1A | |
| SCHEMBL4965561 | 0.78 | KMT2A (0.54) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4965845 | 0.78 | HSD11B1 (0.61) | MEN1KMT2ACCR4HSD17B1HSD11B1 | |
| SCHEMBL4963943 | 0.76 | KDM4E (0.47) | ALDH1A1MAPK1SMN1; SMN2CCR4HSD17B1 | |
| SCHEMBL4965824 | 0.76 | KMT2A (0.51) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4966790 | 0.76 | KDM1A (0.45) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4964551 | 0.76 | MEN1 (0.70) | MEN1KMT2AALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |