Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | CCR4 | P51679 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RORA | P35398 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | USP8 | P40818 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965815 | 0.86 | PDPK1 (0.48) | CCR4ALDH1A1PKMMAPK1SMN1; SMN2 | |
| SCHEMBL4963934 | 0.83 | HSD11B1 (0.49) | CCR4HSD17B1HSD11B1HSD17B2KDM1A | |
| SCHEMBL4965845 | 0.82 | HSD11B1 (0.61) | CCR4EDNRBEDNRAHSD17B1HSD11B1 | |
| SCHEMBL4962685 | 0.81 | MEN1 (0.60) | MAPTALDH1A1PKMSMN1; SMN2CYP2C9 | |
| SCHEMBL4963696 | 0.79 | CCR2 (0.43) | ALDH1A1PKMCYP2C9CYP2C19MEN1 | |
| SCHEMBL4963943 | 0.78 | KDM4E (0.47) | CCR4EDNRBEDNRATSHRALDH1A1 | |
| SCHEMBL4965824 | 0.78 | KMT2A (0.51) | MAPTALDH1A1PKMCYP2C9CYP2C19 | |
| SCHEMBL4964568 | 0.78 | CCR2 (0.45) | MAPTSMN1; SMN2 | |
| SCHEMBL4966790 | 0.78 | KDM1A (0.45) | ALDH1A1CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL4965561 | 0.77 | KMT2A (0.54) | ALDH1A1PKMSMN1; SMN2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |