Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.40 |
| ▸ | ARG1 | P05089 | 3/20 | 0.40 |
| ▸ | ARG2 | P78540 | 2/20 | 0.40 |
| ▸ | GRM8 | O00222 | 2/20 | 0.40 |
| ▸ | GRM6 | O15303 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181380 | 0.85 | — | — | |
| SCHEMBL8443338 | 0.77 | GRM2 (0.41) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL4835740 | 0.77 | SLC6A4 (0.47) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL8438917 | 0.77 | GRM2 (0.41) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL8441724 | 0.77 | GRM2 (0.41) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL7135246 | 0.77 | GRM2 (0.46) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL4835859 | 0.77 | SLC6A4 (0.47) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL2939527 | 0.77 | GRM2 (0.46) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL22415975 | 0.77 | GRM2 (0.41) | GRM2GRM3ARG1ARG2GRM8 | |
| SCHEMBL8440792 | 0.77 | GRM2 (0.41) | GRM2GRM3ARG1ARG2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904100-A1 | NEW COMBINATION OF ANTI-MADCAM ANTIBODY AND ANTIFIBROTIC CASPASE INHIBITOR TO TREAT LIVER FIBROSIS | Pfizer Limited (GB) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007007162-A1 | NEW COMBINATION OF ANTI-MADCAM ANTIBODY AND ANTIFIBROTIC CASPASE INHIBITOR TO TREAT LIVER FIBROSIS | PFIZER LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |