Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.46 |
| ▸ | GRM8 | O00222 | 3/20 | 0.46 |
| ▸ | GRM6 | O15303 | 3/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ARG1 | P05089 | 3/20 | 0.41 |
| ▸ | ARG2 | P78540 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26332225 | 1.00 | SLC6A4 (0.47) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL4835859 | 1.00 | SLC6A4 (0.47) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL4831160 | 0.93 | SLC6A4 (0.48) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL4831107 | 0.93 | SLC6A4 (0.48) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL8828098 | 0.93 | SLC6A4 (0.48) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL4311566 | 0.93 | SLC6A4 (0.48) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL4840309 | 0.93 | SLC6A4 (0.48) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL14662849 | 0.86 | SLC6A4 (0.43) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL3704762 | 0.83 | ARG1 (0.39) | SLC6A4GRM2GRM3GRM8GRM6 | |
| SCHEMBL28507194 | 0.80 | GRM4 (0.41) | SLC6A4GRM2GRM3GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365091-B2 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX | ENOBIA PHARMA (CA) | 2008-04-29 | — | — | US | disclosed |
| US-20060287280-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX | ENOBIA PHARMA (CA) | 2006-12-21 | — | — | US | disclosed |
| US-7105539-B2 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | ENOBIA PHARMA (CA) | 2006-09-12 | — | — | US | disclosed |
| US-20060135480-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | ENOBIA PHARMA (CA) | 2006-06-22 | — | — | US | disclosed |
| US-20040186301-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | BIOMEP INC. | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287280-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX | GLS, SUCNR1, PGD | SLC6A4 1531/4885GRM2 899/4885GRM3 1602/4885 |
| US-20040186301-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | GLS, SUCNR1, PGD | SLC6A4 1569/4885GRM2 860/4885GRM3 1620/4885 |
| US-20060135480-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | GLS, SUCNR1, GCDH | SLC6A4 1602/4885GRM2 871/4885GRM3 1656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.