(S)-Thiorphan

(S)-Thiorphan

SCHEMBL49662

O=C(O)CNC(=O)[C@@H](CS)Cc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MME P08473 6/20 1.00
ACE P12821 3/20 1.00
ALDH1A1 P00352 2/20 1.00
HPGD P15428 1/20 1.00
MAPK1 P28482 1/20 1.00
HSD17B10 Q99714 1/20 1.00
MEN1 O00255 1/20 1.00
MAPT P10636 1/20 1.00
ECE1 P42892 1/20 1.00
BLM P54132 1/20 1.00
NPEPPS P55786 1/20 1.00
KMT2A Q03164 1/20 1.00
CPA3 P15088 1/20 0.62
FOLH1 Q04609 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(R)-Thiorphan SCHEMBL7312756 1.00 MME (1.00) MMEACEALDH1A1HPGDMAPK1
Thiorphan SCHEMBL401174 1.00 MME (1.00) MMEACEALDH1A1HPGDMAPK1
Thiorphan SCHEMBL399227 0.92 MME (0.84) MMEACEALDH1A1HPGDMAPK1
SCHEMBL8861649 0.91 MME (0.83) MMEACEALDH1A1HPGDMAPK1
SCHEMBL10447979 0.90 MME (0.81) MMEACEALDH1A1HPGDMAPK1
Thiorphan SCHEMBL10038977 0.88 MME (0.78) MMEACEALDH1A1HPGDMAPK1
SCHEMBL4442570 0.88 MME (0.78) MMEACEALDH1A1HPGDMAPK1
SCHEMBL10038979 0.88 MME (0.78) MMEACEALDH1A1HPGDMAPK1
SCHEMBL8861684 0.87 MME (0.77) MMEACEALDH1A1HPGDMAPK1
SCHEMBL7103054 0.85 MME (0.74) MMEACEALDH1A1HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3924 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4739291-A2 ADMINISTRATION OF KERATOLYTICS TO OCULAR AND PERIOCULAR SURFACES AZURA OPHTHALMICS LTD (IL) 2026-05-13 EP claimed
US-12605384-B2 Uses INTRA-CELLULAR THERAPIES, INC. (US) 2026-04-21 US claimed
WO-2026041906-A1 SEMI-SOLID PHARMACEUTICAL COMPOSITION MICRO-DISPENSER Azura Ophthalmics Ltd. (IL) 2026-02-26 WO claimed
EP-4595974-A2 THERAPEUTIC COMBINATIONS OF TDFRPS AND ADDITIONAL AGENTS AND METHODS OF USE Carlson, William D. (US) 2025-08-06 EP claimed
WO-2025012701-A2 ADMINISTRATION OF KERATOLYTICS TO OCULAR AND PERIOCULAR SURFACES Azura Ophthalmics Ltd. (IL) 2025-01-16 WO claimed
US-20240189317-A1 ANTIVIRAL COMPOSITIONS AND METHODS ACADIA WOODS PARTNERS, LLC 2024-06-13 US claimed
US-20240123033-A1 THERAPEUTIC COMBINATIONS OF TDFRPs AND ADDITIONAL AGENTS AND METHODS OF USE FOR THE REVERSAL OF FIBROSIS Therapeutics By Design, LLC (US) 2024-04-18 US claimed
EP-4308587-A1 THERAPEUTIC COMBINATIONS OF TDFRPS AND ADDITIONAL AGENTS AND METHODS OF USE FOR THE REVERSAL OF FIBROSIS Therapeutics by Design, LLC (US) 2024-01-24 EP claimed
EP-4308103-A1 ANTIVIRAL COMPOSITIONS AND METHODS AI Therapeutics, Inc. (US) 2024-01-24 EP claimed
US-20230338385-A1 NOVEL USES INTRA-CELLULAR THERAPIES, INC. 2023-10-26 US claimed
EP-0533084-A1 Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating and preventing myointimal proliferation SCHERING CORPORATION (US) 1993-03-24 EP claimed
WO-1992018159-A1 USE OF NEUTRAL ENDOPEPTIDASE INHIBITORS IN THE TREATMENT OF NEPHROTOXICITY SCHERING CORPORATION (US) 1992-10-29 WO claimed
EP-0509442-A1 Use of neutral endopeptidase inhibitors in the treatment of nephrotoxicity SCHERING CORPORATION (US) 1992-10-21 EP claimed
WO-1992013564-A1 COMBINATION OF AN ANGIOTENSIN II ANTAGONIST OR RENIN INHIBITOR WITH A NEUTRAL ENDOPEPTIDASE INHIBITOR SCHERING CORPORATION (US) 1992-08-20 WO claimed
EP-0498361-A2 Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor SCHERING CORPORATION (US) 1992-08-12 EP claimed
US-5084007-A Method for chemical promotion of the effects of low current transcranial electrostimulation MALIN DAVID H (US) 1992-01-28 US claimed
EP-0415693-A1 Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence ARIZONA TECHNOLOGY DEVELOPMENT CORPORATION (US) 1991-03-06 EP claimed
WO-1991001756-A1 METHOD FOR CHEMICAL PROMOTION OF THE EFFECTS OF LOW CURRENT TRANSCRANIAL ELECTROSTIMULATION SKOLNICK MALCOLM H (US) 1991-02-21 WO claimed
US-4740499-A ADMINISTERING WITH THIORPHAN OR KELATORPHAN MONSANTO COMPANY (US) 1988-04-26 US claimed
US-4513009-A GLYCINE, ALANINE AND SERINE DERIVATIVES SOCIETE CIVILE BIOPROJET (FR) 1985-04-23 US claimed