Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.74 |
| ▸ | ACE | P12821 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | ECE1 | P42892 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825762 | 1.00 | MME (0.74) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL10447979 | 0.91 | MME (0.81) | MMEACEALDH1A1ECE1HPGD | |
| Thiorphan SCHEMBL401174 | 0.85 | MME (1.00) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL9622300 | 0.85 | MME (0.72) | MMEACEALDH1A1ECE1HPGD | |
| (R)-Thiorphan SCHEMBL7312756 | 0.85 | MME (1.00) | MMEACEALDH1A1ECE1HPGD | |
| (S)-Thiorphan SCHEMBL49662 | 0.85 | MME (1.00) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL9622302 | 0.85 | MME (0.72) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL10691553 | 0.84 | MME (0.70) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL19437143 | 0.84 | MME (0.70) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL7107731 | 0.82 | CYP1A2 (0.70) | MMEACEALDH1A1ECE1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093625-B2 | Process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-10-09 | — | — | US | claimed |
| US-20170247328-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-08-31 | — | — | US | claimed |
| EP-0937710-B1 | Method for producing an optically active phenylpropionic acid derivative | AJINOMOTO KK (JP) | 2003-04-16 | — | — | EP | claimed |
| US-10093625-B2 | Process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-10-09 | — | — | US | disclosed |
| US-20170247328-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-08-31 | — | — | US | disclosed |
| WO-2011161646-A2 | PROCESS FOR THE PREPARATION OF ALVIMOPAN OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247328-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE | HPD, GRHPR, HCAR2 | MME 3217/4885ACE 442/4885ALDH1A1 15/4885 |
| US-10093625-B2 | Process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate | HPD, HCAR2, GRHPR | MME 2400/4885ACE 425/4885ALDH1A1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.