Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.61 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617311 | 0.88 | SMN1; SMN2 (0.56) | PAX8RAB9ANPC1ALDH1A1TAS2R14 | |
| SCHEMBL617343 | 0.86 | NR1I2 (0.58) | PAX8KDM4EAPOBEC3AAPOBEC3GRAB9A | |
| SCHEMBL616092 | 0.78 | NPC1 (0.55) | PAX8KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL5704502 | 0.77 | ALDH1A1 (0.64) | KDM4EALDH1A1KMT2AMEN1HTT | |
| SCHEMBL618857 | 0.77 | LMNA (0.50) | KDM4ERAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL618899 | 0.77 | NPC1 (0.54) | PAX8KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL13106657 | 0.76 | ALDH1A1 (0.53) | PAX8KDM4EAPOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL17560722 | 0.76 | BRPF1 (0.79) | KMT2A | |
| SCHEMBL616054 | 0.76 | NPC1 (0.53) | KDM4ERAB9ANPC1KMT2AMEN1 | |
| SCHEMBL4589934 | 0.75 | PTPN2 (0.57) | PAX8KDM4EAPOBEC3AAPOBEC3GALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670790-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | claimed |