Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966546 | 1.00 | ACHE (0.42) | ACHEHRH3CHRM5ADRA2C | |
| SCHEMBL10998848 | 0.95 | ACHE (0.47) | ACHEHRH3CHRM5ADRA2C | |
| SCHEMBL13544153 | 0.93 | ACHE (0.50) | ACHEHRH3CHRM5ADRA2C | |
| SCHEMBL1787100 | 0.93 | HRH3 (0.42) | ACHEHRH3 | |
| SCHEMBL22852502 | 0.93 | HRH3 (0.42) | ACHEHRH3 | |
| SCHEMBL14828674 | 0.89 | CHRM5 (0.52) | ACHEHRH3CHRM5ADRA2C | |
| SCHEMBL16254938 | 0.86 | ALDH1A1 (0.44) | ACHEHRH3CHRM5ADRA2C | |
| SCHEMBL16480437 | 0.84 | KCNH2 (0.44) | HRH3 | |
| SCHEMBL5504654 | 0.84 | HRH3 (0.39) | HRH3 | |
| SCHEMBL5504656 | 0.84 | GBA1 (0.44) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888523-A2 | CYCLOBUTYL AMINE DERIVATIVES | Abbott Laboratories (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006132914-A2 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2006-12-14 | — | — | WO | disclosed |