Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30232753 | 0.86 | L3MBTL1 (0.60) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL126054 | 0.86 | L3MBTL1 (0.60) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL2482284 | 0.85 | BRD4 (0.43) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL29922777 | 0.81 | BRD4 (0.60) | GRM4CYP3A4CYP1A2ALDH1A1HSD17B10 | |
| SCHEMBL1187172 | 0.81 | BRD4 (0.60) | GRM4CYP3A4CYP1A2ALDH1A1HSD17B10 | |
| SCHEMBL28430192 | 0.78 | GRM4 (0.43) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL27593401 | 0.78 | GRM4 (0.41) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL31233647 | 0.77 | ALDH1A1 (0.40) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| Bromide SCHEMBL27499524 | 0.77 | GRM4 (0.41) | L3MBTL1GRM4CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL27611622 | 0.76 | ALDH1A1 (0.60) | L3MBTL1CYP3A4CYP1A2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957478-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007061360-A2 | NOVEL 3-BICYCLOCARBONYLAMINOPYRIDINE-2-CARBOXAMIDES OR 3-BICYCLOCARBONYLAMINOPYRAZINE-2-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | disclosed |