Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966979 | 0.85 | L3MBTL1 (0.45) | BRD4GRM4CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL29922777 | 0.84 | BRD4 (0.60) | BRD4GRM4CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL1187172 | 0.84 | BRD4 (0.60) | BRD4GRM4CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30232753 | 0.78 | L3MBTL1 (0.60) | GRM4CYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL126054 | 0.78 | L3MBTL1 (0.60) | GRM4CYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL27611622 | 0.76 | ALDH1A1 (0.60) | BRD4CYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL15714562 | 0.75 | BRD4 (0.47) | BRD4GRM4CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL20659270 | 0.75 | BRD4 (0.47) | BRD4GRM4CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28430192 | 0.74 | GRM4 (0.43) | GRM4CYP1A2CYP3A4ALDH1A1L3MBTL1 | |
| SCHEMBL27593401 | 0.74 | GRM4 (0.41) | GRM4CYP1A2CYP3A4ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375899-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | Array Biopharma, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080864-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-07-15 | — | — | WO | disclosed |