Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599752 | 0.89 | HTT (0.44) | MAPTPOLBPKMALDH1A1KDM4E | |
| SCHEMBL5550215 | 0.81 | KAT2B (0.55) | HRH3MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL5968104 | 0.80 | HRH3 (0.43) | HRH3MAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL16690122 | 0.80 | KAT2B (0.56) | HRH3MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8640471 | 0.76 | ALDH1A1 (0.51) | MAPTPOLBPKMALDH1A1LMNA | |
| SCHEMBL6232184 | 0.76 | MAPT (0.68) | HRH3MAPTHDAC1POLBPKM | |
| SCHEMBL6201353 | 0.75 | MEN1 (0.42) | HRH3POLBRAB9A | |
| SCHEMBL2326316 | 0.75 | PKM (0.61) | HRH3MAPTHDAC1POLBPKM | |
| SCHEMBL14960166 | 0.74 | KAT2B (0.53) | HRH3MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9725427 | 0.74 | MEN1 (0.59) | HRH3MAPTPOLBPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670770-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEROF AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1670770-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEROF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005030733-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEROF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |