Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326316 | 0.85 | PKM (0.61) | MAPTPOLBPKMHDAC1HRH3 | |
| SCHEMBL15544925 | 0.84 | MAPT (0.50) | MAPTPOLBPKMALDH1A1HRH3 | |
| SCHEMBL8107611 | 0.82 | MAPT (0.60) | MAPTPOLBPKMALDH1A1KDM4E | |
| SCHEMBL5257974 | 0.82 | ALDH1A1 (0.65) | MAPTPOLBPKMALDH1A1GAA | |
| SCHEMBL28183332 | 0.82 | HCAR3 (0.65) | MAPTALDH1A1HDAC1KDM4E | |
| SCHEMBL16690122 | 0.82 | KAT2B (0.56) | MAPTALDH1A1HRH3LMNASMN1; SMN2 | |
| SCHEMBL21531168 | 0.81 | MAPT (0.75) | MAPTPOLBPKMALDH1A1HRH3 | |
| SCHEMBL5550215 | 0.81 | KAT2B (0.55) | MAPTALDH1A1HRH3SMN1; SMN2RAB9A | |
| SCHEMBL8147273 | 0.79 | MAPT (0.65) | MAPTPOLBPKMALDH1A1KDM4E | |
| SCHEMBL3998819 | 0.79 | LMNA (0.54) | MAPTPOLBPKMALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |