Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6406694 | 0.82 | ALDH1A1 (0.48) | HDAC4SMN1; SMN2ALDH1A1HSD11B1GAA | |
| SCHEMBL4961923 | 0.77 | ALDH1A1 (0.54) | L3MBTL1HDAC4SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL3553242 | 0.76 | HDAC4 (0.62) | L3MBTL1HDAC4SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL13545175 | 0.73 | HSD11B1 (0.51) | HDAC4SMN1; SMN2ALDH1A1HSD11B1GAA | |
| SCHEMBL1099903 | 0.73 | HDAC4 (0.62) | L3MBTL1HDAC4SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL13543229 | 0.73 | HSD11B1 (0.51) | L3MBTL1HDAC4SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL14036719 | 0.72 | L3MBTL1 (1.00) | L3MBTL1SMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL17285705 | 0.72 | HDAC4 (0.65) | L3MBTL1HDAC4SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL25781021 | 0.71 | L3MBTL1 (0.61) | L3MBTL1SMN1; SMN2ALDH1A1GAAKDM4E | |
| SCHEMBL25460818 | 0.70 | HDAC4 (0.73) | HDAC4SMN1; SMN2ALDH1A1HSD11B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | claimed |
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | L3MBTL1 4602/4885HDAC4 1710/4885SMN1; SMN2 3497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.