Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CPS1 | P31327 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5518141 | 1.00 | MYC (0.42) | MYCALDH1A1LMNAHPGDHIF1A | |
| SCHEMBL31386180 | 0.85 | PDE4B (0.52) | ALDH1A1MEN1KMT2APDE4B | |
| SCHEMBL4982385 | 0.83 | PDE4B (0.55) | PDE4B | |
| SCHEMBL13544329 | 0.83 | ACMSD (0.45) | ALDH1A1HPGDKDM4EPDE4BPDE4A | |
| SCHEMBL3903392 | 0.82 | ACMSD (0.47) | ALDH1A1HPGDKDM4E | |
| SCHEMBL25953850 | 0.80 | SLC6A3 (0.44) | ALDH1A1HPGDKDM4E | |
| SCHEMBL15778750 | 0.80 | SLC6A3 (0.44) | ALDH1A1HPGDKDM4E | |
| SCHEMBL27195828 | 0.79 | QDPR (0.50) | ALDH1A1LMNAHPGDKDM4EKMT2A | |
| SCHEMBL26106200 | 0.77 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL27722668 | 0.77 | MAPK1 (0.38) | ALDH1A1LMNAHPGDHIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2014-10-02 | — | — | US | disclosed |
| US-8697736-B2 | 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors | ABBVIE INC. (US) | 2014-04-15 | — | — | US | disclosed |
| WO-2012038751-A3 | PROCESS FOR THE PURIFICATION OF AROMATIC DICARBOXYLIC ACID | DAVY PROCESS TECHNOLOGY LIMITED (GB) | 2012-05-10 | — | — | WO | disclosed |
| EP-1957477-B1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LAB (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-1957477-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2008-08-20 | — | — | EP | disclosed |
| US-20070179136-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-08-02 | — | — | US | disclosed |
| WO-2007041357-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | MYC 1949/4885ALDH1A1 193/4885LMNA 320/4885 |
| US-20070179136-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | MYC 1986/4885ALDH1A1 199/4885LMNA 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.