Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969348 | 0.87 | HTR6 (0.45) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4969052 | 0.85 | HTR6 (0.49) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4972726 | 0.84 | HTR6 (0.41) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4972774 | 0.83 | MEN1 (0.41) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4968907 | 0.83 | HTR6 (0.41) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4971672 | 0.79 | HTR6 (0.43) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4971454 | 0.77 | HTR6 (0.41) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4971283 | 0.77 | HTR6 (0.39) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL4971034 | 0.76 | KMT2A (0.40) | HTR6HTR1AHTR2AHTR7MEN1 | |
| SCHEMBL15265192 | 0.76 | MEN1 (0.50) | HTR6HTR1AHTR2AHTR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |