Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 7/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 2/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970766 | 0.89 | HTR6 (0.42) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4969052 | 0.85 | HTR6 (0.49) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4968907 | 0.84 | HTR6 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4972726 | 0.82 | HTR6 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4971454 | 0.79 | HTR6 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4971672 | 0.78 | HTR6 (0.43) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4972774 | 0.78 | MEN1 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4972772 | 0.77 | HTR6 (0.39) | KMT2AHTR6 | |
| SCHEMBL346299 | 0.77 | TSPO (0.49) | KMT2AMEN1TSPOELANECCKBR | |
| SCHEMBL4967820 | 0.76 | HTR6 (0.43) | KMT2AMEN1HTR6HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |