SCHEMBL4968609

SCHEMBL4968609

C=C(C)C(=O)OCCC[SiH](O[Si](C)(C)C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
POLB P06746 1/20 0.37
APEX1 P27695 1/20 0.37
HTT P42858 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
THRB P10828 1/20 0.37
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7629287 0.91 TSHR (0.50) TSHRPOLBAPEX1HTTTDP1
SCHEMBL1718932 0.87 TSHR (0.53) TSHRPOLBAPEX1HTTTDP1
SCHEMBL396695 0.82 THRB (0.46) TSHRPOLBAPEX1HTTTDP1
SCHEMBL6908183 0.82 TSHR (0.46) TSHRTHRBALDH1A1
SCHEMBL10538774 0.80 TSHR (0.38) TSHRPOLBAPEX1HTTTDP1
SCHEMBL8167209 0.80 TSHR (0.47) TSHRPOLBAPEX1HTTTDP1
SCHEMBL9001633 0.78 TSHR (0.46) TSHRPOLBAPEX1HTTTDP1
SCHEMBL10793367 0.78 TSHR (0.49) TSHRPOLBAPEX1HTTTDP1
SCHEMBL1293374 0.78 TSHR (0.49) TSHRPOLBAPEX1HTTTDP1
SCHEMBL9421226 0.77 TSHR (0.45) TSHRPOLBAPEX1HTTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109476824-B Two-component plaster material and use thereof 喜利得股份公司 2021-03-09 CN claimed
CN-113004528-A Contact lens and surfactant for contact lens 菁眸生物科技(上海)有限公司 2021-06-22 CN disclosed
CN-109476824-B Two-component plaster material and use thereof 喜利得股份公司 2021-03-09 CN disclosed
EP-1927882-B1 Contact lens NOVARTIS AG (CH) 2015-09-23 EP disclosed
EP-1236068-B1 CONTACT LENS NOVARTIS AG (CH) 2008-08-27 EP disclosed
EP-1927882-A2 Contact lens Novartis AG (CH) 2008-06-04 EP disclosed
US-7201481-B2 Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer NOVARTIS AG (CH) 2007-04-10 US disclosed
EP-1236068-A4 CONTACT LENS NOVARTIS AG (CH) 2007-03-28 EP disclosed
US-20060012751-A1 Contact lens ALCON INC. (CH) 2006-01-19 US disclosed
US-20040161445-A1 Hearing aid or hearing aid components for placement in the auditory canal and/or the auricle of a wearer AS AUDIO SERVICE GMBH 2004-08-19 US disclosed
US-6649722-B2 Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer NOVARTIS AG (CH) 2003-11-18 US disclosed
EP-1236068-A1 CONTACT LENS Novartis AG (CH) 2002-09-04 EP disclosed
US-20020107337-A1 Contact lens ALCON INC. (CH) 2002-08-08 US disclosed
WO-2001042846-A1 CONTACT LENS WESLEY JESSEN CORPORATION (US) 2001-06-14 WO disclosed