SCHEMBL9001633

SCHEMBL9001633

C=C(C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.46
THRB P10828 1/20 0.40
POLB P06746 1/20 0.37
APEX1 P27695 1/20 0.37
HTT P42858 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9421226 0.98 TSHR (0.45) TSHRTHRBPOLBAPEX1HTT
SCHEMBL8167209 0.98 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT
SCHEMBL11033007 0.94 TSHR (0.44) TSHRTHRBPOLBAPEX1HTT
SCHEMBL35807 0.94 TSHR (0.51) TSHRTHRBPOLBAPEX1HTT
SCHEMBL333002 0.92 TSHR (0.50) TSHRTHRBPOLBAPEX1HTT
SCHEMBL9418354 0.89 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT
SCHEMBL11312944 0.89 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT
Methacrylic Acid SCHEMBL29583152 0.89 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT
Methacrylic Acid SCHEMBL15856026 0.89 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT
SCHEMBL11312974 0.89 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP claimed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US claimed
US-5519069-A INTERPENETRATING POLYMER NETWORK, TWO CROSSLINKERS, PRECISION CASTING PILKINGTON BARNES HIND, INC. (US) 1996-05-21 US disclosed
US-5505884-A PREPARING FIRST AND SECOND MIXTURES OF POLYMERIZABLE VINYL MONOMERS, INTERRUPTING POLYMERIZATION OF THE FIRST MIXTURE BY MIXING WITH SECOND MIXTURE TO PREPARE CASTING SOLUTION, POLYMERIZING PILKINGTON BARNES HIND INC. (US) 1996-04-09 US disclosed
EP-0345994-B1 Contact lenses and materials and methods of making same PILKINGTON BARNES HIND INC (US) 1995-08-02 EP disclosed
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP disclosed
US-5087392-A Controlled cast molding; interrupting polymerization of first mixture of vinyl monomers by reacting with second; heating; efficient SOLA USA, INC. (US) 1992-02-11 US disclosed
EP-0192683-B1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1989-12-20 EP disclosed
EP-0345994-A2 Contact lenses and materials and methods of making same PILKINGTON BARNES HIND, INC. (US) 1989-12-13 EP disclosed
EP-0184924-B1 LENS COMPOSITION, ARTICLES AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1988-11-30 EP disclosed
US-4769431-A Polyacryloxyalkylsilanol lens composition, articles and method of manufacture PARAGON OPTICAL INC. (US) 1988-09-06 US disclosed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US disclosed
EP-0192683-A4 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE. PARAGON OPTICAL INC (US) 1987-02-19 EP disclosed
EP-0192683-A1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE. PARAGON OPTICAL INC (US) 1986-09-03 EP disclosed
EP-0184924-A2 Lens composition, articles and method of manufacture PARAGON OPTICAL INC (US) 1986-06-18 EP disclosed
US-4582884-A Lens composition, article and method of manufacture PARAGON OPTICAL, INC. (US) 1986-04-15 US disclosed
WO-1986001518-A1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL, INC. (US) 1986-03-13 WO disclosed