Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001633 | 0.98 | TSHR (0.46) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL9421226 | 0.97 | TSHR (0.45) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL11033007 | 0.93 | TSHR (0.44) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL35807 | 0.92 | TSHR (0.51) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL333002 | 0.90 | TSHR (0.50) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5837877 | 0.89 | TSHR (0.49) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL18719914 | 0.88 | TSHR (0.47) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL11312974 | 0.88 | TSHR (0.47) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL11312944 | 0.88 | TSHR (0.47) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL4972438 | 0.88 | TSHR (0.47) | TSHRTHRBPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087412-A | OPHTHALMIC MOLDING BLEND OF MACROMOLECULE CONTAINING PHOTOINITIATOR, HYDROPHILIC VINYL MONOMER AND CROSSLINKER | NOVARTIS AG (CH) | 2000-07-11 | — | — | US | disclosed |
| US-5362767-A | Copolymers comprising propellanes and contact lenses made therefrom | CIBA-GEIGY CORPORATION (US) | 1994-11-08 | — | — | US | disclosed |
| US-5264878-A | Polymers and hard, gas-permeable contact lenses made therefrom | CIBA-GEIGY CORPORATION (US) | 1993-11-23 | — | — | US | disclosed |
| US-5196493-A | Siloxane monvinyl and oligonvinyl components with fluoroacrylate and hydrophobic vinyl component having bulky hydrocarbon radical | CIBA-GEIGY CORPORATION (US) | 1993-03-23 | — | — | US | disclosed |