Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263178 | 0.88 | ACACB (0.45) | ACACBKMT2AMEN1KDM4EMAPT | |
| SCHEMBL13550944 | 0.85 | SIRT2 (0.44) | ACACBPKMFFAR1ALDH1A1 | |
| SCHEMBL9835011 | 0.84 | KMT2A (0.47) | ACACBKMT2AMEN1KDM4EMAPT | |
| SCHEMBL3604889 | 0.84 | ACACB (0.49) | ACACBKMT2AMEN1KDM4EMAPT | |
| SCHEMBL5759509 | 0.84 | ACACB (0.46) | ACACBKMT2AMEN1KDM4EMAPT | |
| SCHEMBL7081683 | 0.84 | ACACB (0.49) | ACACBKMT2AMEN1KDM4EMAPT | |
| SCHEMBL12241779 | 0.83 | P2RX3 (0.43) | KMT2AMEN1LMNAFFAR1SMN1; SMN2 | |
| SCHEMBL18057307 | 0.82 | CPB2 (0.56) | — | |
| SCHEMBL762459 | 0.82 | RAB9A (0.50) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL23792321 | 0.81 | KLKB1 (0.45) | ACACBKMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008113835-A1 | PROCESS FOR PREPARING (R OR S)-5-{1-AZIDO-3-[6-METHOXY-5-(3-METHOXY-PROPOXY)-PYRIDIN-3-YLMETHYL]-4-METHYL-PENTYL}-3-ALKYL-DIHYDRO-FURAN-2-ONE | NOVARTIS AG (CH) | 2008-09-25 | — | — | WO | disclosed |