Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172805 | 0.84 | L3MBTL1 (0.56) | SMN1; SMN2KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL27799601 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AHSD17B10MAPT | |
| SCHEMBL27799074 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL27512024 | 0.75 | CYP1A2 (0.46) | SMN1; SMN2KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL27537297 | 0.75 | ALDH1A1 (0.50) | SMN1; SMN2KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL27336449 | 0.74 | ALDH1A1 (0.47) | SMN1; SMN2KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL27431258 | 0.74 | KMT2A (0.39) | SMN1; SMN2KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL27338326 | 0.74 | KMT2A (0.35) | SMN1; SMN2KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL10850013 | 0.74 | MEN1 (0.39) | SMN1; SMN2KMT2ANPC1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL6216370 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2KMT2AL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |
| EP-1587800-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | Astellas Pharma Inc. (JP) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004067521-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-08-12 | — | — | WO | disclosed |