Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968801 | 0.84 | SMN1; SMN2 (0.51) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E | |
| SCHEMBL10541285 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AKDM4EMAPTNPC1 | |
| SCHEMBL6641922 | 0.80 | SMN1; SMN2 (0.37) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E | |
| SCHEMBL4841581 | 0.75 | MAPK1 (0.56) | SMN1; SMN2HSD17B10MAPTNPC1MAPK1 | |
| SCHEMBL48394 | 0.74 | MAPT (0.66) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E | |
| SCHEMBL11350463 | 0.74 | L3MBTL1 (0.62) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E | |
| SCHEMBL19994395 | 0.74 | MAPT (0.66) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E | |
| SCHEMBL2771532 | 0.74 | RAB9A (0.38) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| SCHEMBL13681839 | 0.73 | L3MBTL1 (0.61) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E | |
| SCHEMBL1938172 | 0.73 | SMN1; SMN2 (0.62) | L3MBTL1SMN1; SMN2KMT2AHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534693-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004022523-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | claimed |