Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.63 |
| ▸ | HTR2C | P28335 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.55 |
| ▸ | HTR3B | O95264 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.53 |
| ▸ | HTR6 | P50406 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR5A | P47898 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560188 | 0.81 | HTR2A (0.63) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL4008999 | 0.80 | HTR2A (0.61) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL5379037 | 0.78 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL5223620 | 0.78 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL5373371 | 0.78 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL4014210 | 0.78 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL1045944 | 0.78 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL1048620 | 0.76 | HTR2A (0.97) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL3560924 | 0.75 | HTR6 (0.56) | HTR2AHTR2CSLC6A4HTR3EHTR3B | |
| SCHEMBL5372201 | 0.75 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888559-A2 | PIPERAZINE-PIPERIDINE ANTAGONISTS AND AGONISTS OF THE 5-HT1A RECEPTOR | Wyeth a Corporation of the State of Delaware (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006135839-A2 | PIPERAZINE-PIPERIDINE ANTAGONISTS AND AGONISTS OF THE 5-HT1A RECEPTOR | WYETH (US) | 2006-12-21 | — | — | WO | disclosed |