Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970299 | 0.91 | CCR3 (0.52) | SIGMAR1HTR1ACYP2C9CYP2C19MAPK14 | |
| SCHEMBL4968189 | 0.90 | CCR3 (0.51) | SIGMAR1HTR1ACYP2C9CYP2C19MAPK14 | |
| SCHEMBL4969159 | 0.82 | HRH1 (0.57) | CCR3HRH1KCNH2 | |
| SCHEMBL4968718 | 0.78 | HRH1 (0.62) | CCR3HRH1KCNH2 | |
| SCHEMBL4969175 | 0.75 | MAPT (0.53) | SIGMAR1CCR3ALDH1A1KDM4EHRH1 | |
| SCHEMBL4968548 | 0.75 | HRH1 (0.58) | CCR3HRH1KCNH2 | |
| SCHEMBL4967412 | 0.72 | CCR3 (0.55) | SIGMAR1CCR3MEN1KMT2AHRH1 | |
| SCHEMBL4968656 | 0.72 | HRH1 (0.56) | CCR3HRH1KCNH2 | |
| SCHEMBL4970174 | 0.72 | HRH1 (0.60) | CCR3HRH1KCNH2 | |
| SCHEMBL4965723 | 0.70 | CCR3 (0.57) | CCR3HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |