Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1595147 | 0.79 | PRKCA (0.41) | CES2CES1PPARGPPARAFFAR1 | |
| SCHEMBL1595149 | 0.79 | PRKCA (0.41) | CES2CES1PPARGPPARAFFAR1 | |
| SCHEMBL1743778 | 0.76 | PRKCA (0.38) | CES2CES1PPARGPPARAFFAR1 | |
| SCHEMBL1743782 | 0.76 | PRKCA (0.38) | CES2CES1PPARGPPARAFFAR1 | |
| SCHEMBL1743781 | 0.76 | PRKCA (0.38) | CES2CES1PPARGPPARAFFAR1 | |
| SCHEMBL17634288 | 0.74 | GSK3B (0.45) | CES2CES1AKR1C3AKR1C2PPARG | |
| SCHEMBL7356998 | 0.73 | LMNA (0.40) | AKR1C3AKR1C2FFAR1ALDH1A1 | |
| SCHEMBL4659430 | 0.71 | GRM8 (0.38) | CES2CES1AKR1C3AKR1C2PPARG | |
| SCHEMBL1742715 | 0.71 | ALDH1A1 (0.36) | CES2CES1PPARGPPARAFFAR1 | |
| SCHEMBL1742709 | 0.71 | ALDH1A1 (0.36) | CES2CES1PPARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |