Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403404 | 0.94 | CHRM1 (0.56) | CHRM1RAB9ANPC1CHRM4CHRM2 | |
| SCHEMBL4975172 | 0.92 | CHRM1 (0.56) | CHRM1RAB9ANPC1CHRM4CHRM2 | |
| SCHEMBL4971259 | 0.90 | RAB9A (0.48) | RAB9ASMOKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL4971048 | 0.88 | RAB9A (0.50) | RAB9ANPC1SMOKCNQ3KCNQ2 | |
| SCHEMBL4967854 | 0.88 | SMO (0.57) | CHRM1RAB9ANPC1CHRM4CHRM2 | |
| SCHEMBL4968097 | 0.86 | HDAC2 (0.60) | RAB9ASMOKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL404119 | 0.85 | CHRM1 (0.66) | CHRM1RAB9ANPC1CHRM4CHRM2 | |
| SCHEMBL4969870 | 0.85 | SMO (0.50) | RAB9ANPC1SMOKCNQ3KCNQ2 | |
| SCHEMBL4970125 | 0.85 | SMO (0.48) | RAB9ANPC1SMOKCNQ3KCNQ2 | |
| SCHEMBL402855 | 0.83 | SMO (0.52) | RAB9ANPC1SMOKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |