Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27955217 | 0.87 | MAPT (0.56) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL1515798 | 0.85 | MAPT (0.61) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL15100944 | 0.81 | MAPT (0.60) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL1515782 | 0.81 | MAPT (0.60) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL4846480 | 0.80 | MAPT (0.53) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL14533992 | 0.79 | MAPT (0.57) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL4949504 | 0.78 | ACHE (0.42) | MAPTRAB9ANPC1ALDH1A1POLB | |
| SCHEMBL2953875 | 0.78 | PTPN1 (0.57) | CES2CES1 | |
| SCHEMBL1515818 | 0.77 | L3MBTL1 (0.65) | MAPTL3MBTL1SRD5A2RAB9ASMN1; SMN2 | |
| SCHEMBL3497492 | 0.77 | KMT2A (0.58) | MAPTL3MBTL1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099020-A1 | 1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008099020-A1 | 1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |