Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28588853 | 0.86 | HDAC4 (0.58) | HDAC4HDAC2HDAC8NPC1RAB9A | |
| SCHEMBL16109474 | 0.85 | HDAC4 (0.65) | HDAC4HDAC2HDAC8SMN1; SMN2MAPT | |
| SCHEMBL1638395 | 0.83 | APP (0.50) | RAB9ASMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL18083450 | 0.82 | ACHE (0.44) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL19084974 | 0.82 | CYP1A1 (0.56) | NPC1RAB9ASMN1; SMN2MAPTCRHBP | |
| SCHEMBL20110010 | 0.81 | L3MBTL1 (0.51) | HDAC4HDAC2HDAC8ALDH1A1CYP1A2 | |
| SCHEMBL10227201 | 0.81 | APP (0.48) | RAB9ASMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL9272421 | 0.81 | CYP1A2 (0.63) | HDAC4HDAC2HDAC8NPC1RAB9A | |
| SCHEMBL19486099 | 0.81 | BRD4 (0.47) | SMN1; SMN2MAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL22285911 | 0.81 | CA12 (0.52) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1965785-A1 | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR | N.V. Organon (NL) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071638-A1 | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR | N.V. ORGANON (NL) | 2007-06-28 | — | — | WO | disclosed |