Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968252 | 0.88 | CYP11B1 (0.38) | CYP11B1CYP11B2KMT2AMEN1HTR6 | |
| SCHEMBL4968898 | 0.82 | MEN1 (0.44) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4971283 | 0.81 | HTR6 (0.39) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4972774 | 0.77 | MEN1 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4969052 | 0.76 | HTR6 (0.49) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4967820 | 0.75 | HTR6 (0.43) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4971672 | 0.74 | HTR6 (0.43) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4968907 | 0.74 | HTR6 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL4971454 | 0.73 | HTR6 (0.41) | KMT2AMEN1HTR6HTR1AHTR2A | |
| SCHEMBL15265192 | 0.72 | MEN1 (0.50) | KMT2AMEN1HTR6HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |