Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515708 | 0.88 | LMNA (0.44) | SMN1; SMN2TDP1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL5877045 | 0.86 | L3MBTL1 (0.53) | TDP1L3MBTL1POLBALDH1A1MAPT | |
| SCHEMBL1515750 | 0.86 | L3MBTL1 (0.53) | TDP1L3MBTL1POLBALDH1A1MAPT | |
| SCHEMBL1515800 | 0.80 | CES2 (0.42) | SMN1; SMN2L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL5898854 | 0.79 | TUBB1 (0.49) | SMN1; SMN2TDP1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL3504212 | 0.76 | GAA (0.38) | SMN1; SMN2LMNAALDH1A1GRM2GRM3 | |
| SCHEMBL1515821 | 0.76 | CYP3A4 (0.46) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL1515694 | 0.75 | ACP3 (0.56) | L3MBTL1LMNACNR2ALDH1A1MAPT | |
| SCHEMBL1515778 | 0.74 | CHRM2 (0.48) | TDP1L3MBTL1 | |
| SCHEMBL4971811 | 0.74 | SMN1; SMN2 (0.36) | SMN1; SMN2TDP1L3MBTL1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062308-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |