Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972650 | 0.89 | KDM4E (0.47) | MAPK14ALDH1A1KDM4EKMT2APOLB | |
| SCHEMBL4972421 | 0.84 | MAPK14 (0.46) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2473620 | 0.83 | MAPK14 (0.42) | MAPK14ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL2475615 | 0.83 | MAPK14 (0.51) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4973347 | 0.82 | GAA (0.50) | MAPK14ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL4974109 | 0.82 | GAA (0.53) | MAPK14ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL4971053 | 0.81 | NPSR1 (0.48) | MAPK14ALDH1A1TSHRMAPK8TP53 | |
| SCHEMBL4971842 | 0.81 | GABRA5 (0.51) | MAPK14ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL2472200 | 0.80 | PTGS2 (0.59) | MAPK14ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL4973172 | 0.78 | PTGS2 (0.48) | MAPK14ALDH1A1KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |