Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL151456 | 0.97 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL619046 | 0.97 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL2029680 | 0.97 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL18839954 | 0.97 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL104934 | 0.97 | — | — | |
| Succinic Acid SCHEMBL11154339 | 0.97 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL155053 | 0.97 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL7567030 | 0.94 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL22656795 | 0.94 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL31277093 | 0.94 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861280-A | Cottonseed globulin positive charge antibacterial peptide and application thereof | 晨光生物科技集团股份有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-101565739-B | Method for measuring purity of papain by fast protein liquid chromatogram | UNIV DONGHUA | 2013-06-05 | — | — | CN | disclosed |
| CN-101919810-B | Dexpanthenol infusion preparation and preparation method thereof | HEBEI KINGSCI PHARMACEUTICAL TECHNOLOGY CO LTD | 2013-03-06 | — | — | CN | disclosed |
| US-8106002-B2 | Anti-cancer agent comprising protein C inhibitor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-01-31 | — | — | US | disclosed |
| CN-101919810-A | Dexpanthenol infusion preparation and preparation method thereof | HEBEI KINGSCI PHARMACEUTICAL TECHNOLOGY CO LTD | 2010-12-22 | — | — | CN | disclosed |
| CN-101565739-A | Method for measuring purity of papain by fast protein liquid chromatogram | UNIV DONGHUA (CN) | 2009-10-28 | — | — | CN | disclosed |
| US-20090170760-A1 | Anti-Cancer Agent Comprising Protein C Inhibitor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-1894574-A1 | ANTI-CANCER AGENT COMPRISING PROTEIN C INHIBITOR | Mie University (JP) | 2008-03-05 | — | — | EP | disclosed |