Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967797 | 0.81 | CA9 (0.34) | MAPTKMT2AMEN1GAA | |
| SCHEMBL4017459 | 0.78 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL6187691 | 0.78 | AKR1B1 (0.39) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL28101785 | 0.70 | AKR1B1 (0.41) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL2061536 | 0.70 | AKR1B1 (0.44) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL2062098 | 0.70 | AKR1B1 (0.44) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL429310 | 0.69 | MAPT (0.57) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL15656347 | 0.69 | NR3C2 (0.39) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL15497921 | 0.68 | ALDH1A1 (0.44) | PNMTADRA2AADRA2BADRA2CMAPT | |
| Hydrochloric Acid SCHEMBL4967505 | 0.68 | MAPT (0.56) | PNMTADRA2AADRA2BADRA2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| EP-1697361-A1 | BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | Renovis, Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005066171-A1 | BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF | RENOVIS, INC. (US) | 2005-07-21 | — | — | WO | disclosed |