Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484227 | 0.79 | CMA1 (0.39) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL2776785 | 0.78 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL4970728 | 0.78 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4429953 | 0.76 | PNMT (0.52) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL13233996 | 0.75 | GRIN2B (0.42) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL6195263 | 0.75 | SIRT2 (0.45) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL7456470 | 0.74 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL6197463 | 0.74 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL28439970 | 0.74 | ALDH1A1 (0.41) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL8702101 | 0.72 | GRIN2B (0.42) | PNMTADRA2AADRA2BADRA2CGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |