SCHEMBL4970799

SCHEMBL4970799

C=C(C)C(=O)OCC(CCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C)NC(=O)O

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.39
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8762857 0.82 TSHR (0.39) TSHRALDH1A1
SCHEMBL9421345 0.79 TSHR (0.40) TSHRALDH1A1
SCHEMBL4895752 0.76 TSHR (0.42) TSHRALDH1A1
SCHEMBL9421349 0.73 TSHR (0.33) TSHR
SCHEMBL1554134 0.73 CYP2D6 (0.30)
SCHEMBL35807 0.73 TSHR (0.51) TSHRALDH1A1
Methacrylic Acid SCHEMBL29583152 0.73 TSHR (0.47) TSHRALDH1A1
Methacrylic Acid SCHEMBL15856026 0.73 TSHR (0.47) TSHRALDH1A1
SCHEMBL9418354 0.73 TSHR (0.47) TSHRALDH1A1
SCHEMBL9614390 0.72 THRB (0.34) TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1927882-B1 Contact lens NOVARTIS AG (CH) 2015-09-23 EP disclosed
EP-1236068-B1 CONTACT LENS NOVARTIS AG (CH) 2008-08-27 EP disclosed
EP-1927882-A2 Contact lens Novartis AG (CH) 2008-06-04 EP disclosed
US-7201481-B2 Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer NOVARTIS AG (CH) 2007-04-10 US disclosed
US-20060012751-A1 Contact lens ALCON INC. (CH) 2006-01-19 US disclosed
US-6649722-B2 Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer NOVARTIS AG (CH) 2003-11-18 US disclosed
US-20020107337-A1 Contact lens ALCON INC. (CH) 2002-08-08 US disclosed
EP-0781777-A1 Silicon-containing compound and ocular lens material Menicon Co., Ltd. (JP) 1997-07-02 EP disclosed