Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947953 | 0.85 | REN (0.46) | RENKIF11MAPK1NPSR1L3MBTL1 | |
| SCHEMBL4973124 | 0.84 | REN (0.52) | REN | |
| SCHEMBL4972346 | 0.83 | REN (0.47) | REN | |
| SCHEMBL4752903 | 0.82 | REN (0.53) | RENKIF11 | |
| SCHEMBL5510417 | 0.82 | REN (0.53) | RENKIF11 | |
| SCHEMBL3611603 | 0.82 | REN (0.53) | REN | |
| SCHEMBL968751 | 0.82 | REN (0.53) | REN | |
| SCHEMBL968749 | 0.82 | REN (0.53) | REN | |
| SCHEMBL4970848 | 0.78 | HRH3 (0.35) | RENKIF11MAPK1NPSR1L3MBTL1 | |
| SCHEMBL4752797 | 0.77 | KIF11 (0.46) | RENKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |