Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1364227 | 1.00 | DRD2 (0.45) | DRD2KDM1AMAOAMAOBADRA1A | |
| SCHEMBL240094 | 0.89 | DRD2 (0.51) | DRD2KDM1AMAOAMAOBADRA1A | |
| SCHEMBL1366601 | 0.80 | HTR2C (0.58) | DRD2KDM1AADRA1AMEN1KMT2A | |
| SCHEMBL1363924 | 0.79 | KDM1A (0.46) | KDM1AMAOASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1366298 | 0.79 | SLC18A3 (0.38) | ALDH1A1SMN1; SMN2ATMTDP1 | |
| SCHEMBL1515026 | 0.78 | DRD2 (0.59) | DRD2KDM1AMAOAMAOBADRA1A | |
| SCHEMBL2426702 | 0.77 | L3MBTL1 (0.40) | KDM1AMEN1KMT2ASLC6A4 | |
| SCHEMBL1366303 | 0.76 | CYP19A1 (0.36) | ALDH1A1SMN1; SMN2DDB1CRBNTDP1 | |
| SCHEMBL1366932 | 0.75 | HTR3A (0.46) | DRD2ADRA1AALDH1A1MEN1KMT2A | |
| SCHEMBL1365553 | 0.75 | KDM1A (0.38) | KDM1AALDH1A1SMN1; SMN2ATMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991540-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098214-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |