Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | PYGL | P06737 | 3/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134272 | 0.82 | ALDH1A1 (0.58) | POLBGAAMAPTRECQLKDM4E | |
| SCHEMBL3135239 | 0.82 | PYGL (0.69) | POLBGAAMAPTRECQLKDM4E | |
| SCHEMBL3138705 | 0.82 | PYGL (0.57) | POLBGAAMAPTRECQLKDM4E | |
| SCHEMBL13449296 | 0.81 | ALDH1A1 (0.54) | POLBGAAMAPTRECQLKDM4E | |
| SCHEMBL8435221 | 0.81 | PYGL (0.58) | POLBGAAMAPTRECQLKDM4E | |
| SCHEMBL8242777 | 0.81 | MAPT (0.53) | POLBGAAMAPTRECQLKDM4E | |
| SCHEMBL28464698 | 0.75 | CYP1A2 (0.51) | GAAMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL20601617 | 0.73 | PYGL (0.83) | KDM4EALDH1A1KMT2ASMN1; SMN2PYGL | |
| SCHEMBL7337275 | 0.73 | HTT (0.58) | POLBGAAMAPTKDM4EALDH1A1 | |
| SCHEMBL4699957 | 0.73 | PYGL (0.71) | MAPTKDM4EALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984342-A2 | NOVEL SOLID FORMS OF (4R)-1-[4-(2-CHLORO-5-FLUOROBENZOYL)AMINO-3-METHOXYBENZOYL]-1,2,3,5-TETRAHYDRO-SPIRO[4H-1-BENZAZEPINE-4,1'-[2]CYCLOPENTENE]-3'-CARBOXYLIC ACID | Janssen Pharmaceutica, N.V. (BE) | 2008-10-29 | — | — | EP | claimed |
| WO-2007084591-A2 | NOVEL SOLID FORMS OF (4R)-1-[4-(2-CHLORO-5-FLUOROBENZOYL)AMINO-3-METHOXYBENZOYL]-1,2,3,5-TETRAHYDRO-SPIRO[4H-1-BENZAZEPINE-4,1'-[2]CYCLOPENTENE]-3'-CARBOXYLIC ACID | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | claimed |
| EP-1984342-A2 | NOVEL SOLID FORMS OF (4R)-1-[4-(2-CHLORO-5-FLUOROBENZOYL)AMINO-3-METHOXYBENZOYL]-1,2,3,5-TETRAHYDRO-SPIRO[4H-1-BENZAZEPINE-4,1'-[2]CYCLOPENTENE]-3'-CARBOXYLIC ACID | Janssen Pharmaceutica, N.V. (BE) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084591-A2 | NOVEL SOLID FORMS OF (4R)-1-[4-(2-CHLORO-5-FLUOROBENZOYL)AMINO-3-METHOXYBENZOYL]-1,2,3,5-TETRAHYDRO-SPIRO[4H-1-BENZAZEPINE-4,1'-[2]CYCLOPENTENE]-3'-CARBOXYLIC ACID | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |