Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | PYGL | P06737 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13449297 | 0.88 | MAPT (0.53) | ALDH1A1KMT2AMAPTGAATAS1R3 | |
| SCHEMBL3134272 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL3135239 | 0.82 | PYGL (0.69) | ALDH1A1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL3138705 | 0.82 | PYGL (0.57) | ALDH1A1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL8242777 | 0.81 | MAPT (0.53) | ALDH1A1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL4971900 | 0.81 | POLB (0.53) | ALDH1A1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL8435221 | 0.81 | PYGL (0.58) | ALDH1A1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL6640602 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL20601617 | 0.75 | PYGL (0.83) | ALDH1A1KDM4EKMT2APYGLSMN1; SMN2 | |
| SCHEMBL28464698 | 0.75 | CYP1A2 (0.51) | ALDH1A1KDM4EKMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687494-B2 | Substituted spirobenzazepines | JANSSEN PHARMACEUTICA NV (BE) | 2010-03-30 | — | — | US | disclosed |