Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968254 | 0.88 | REN (0.47) | RENCYP3A4 | |
| SCHEMBL4973673 | 0.88 | REN (0.47) | RENCYP3A4 | |
| SCHEMBL4972485 | 0.83 | REN (0.61) | RENCYP3A4 | |
| SCHEMBL3881752 | 0.82 | REN (0.52) | RENHRH3 | |
| SCHEMBL2332375 | 0.81 | REN (0.50) | RENCYP3A4 | |
| SCHEMBL2332382 | 0.81 | REN (0.50) | RENCYP3A4 | |
| SCHEMBL2332378 | 0.81 | REN (0.50) | RENCYP3A4 | |
| SCHEMBL4974117 | 0.81 | SLC6A2 (0.40) | RENCYP3A4 | |
| SCHEMBL4971315 | 0.79 | REN (0.49) | RENCYP3A4 | |
| SCHEMBL4973471 | 0.79 | REN (0.43) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |