Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968254 | 1.00 | REN (0.47) | RENCYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4971315 | 0.91 | REN (0.49) | RENCYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4972006 | 0.88 | REN (0.41) | RENCYP3A4 | |
| SCHEMBL4974117 | 0.87 | SLC6A2 (0.40) | RENCYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4974711 | 0.84 | REN (0.43) | RENCYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL4972582 | 0.84 | REN (0.49) | RENCYP3A4 | |
| SCHEMBL3965440 | 0.83 | REN (0.62) | RENCYP3A4 | |
| SCHEMBL4970054 | 0.82 | REN (0.36) | REN | |
| SCHEMBL968756 | 0.82 | REN (0.54) | RENCYP3A4 | |
| SCHEMBL968755 | 0.82 | REN (0.54) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |