Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295550 | 0.89 | KDM1A (0.43) | LTA4HKDM1ALIPESMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL4283402 | 0.88 | KDM1A (0.42) | LTA4HKDM1ALIPESMN1; SMN2RAB9A | |
| SCHEMBL3491813 | 0.86 | GPR119 (0.42) | LTA4HADRB1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4975002 | 0.84 | MAPT (0.46) | LTA4HADRB1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL4288512 | 0.82 | LTA4H (0.52) | LTA4HADRB1PARP1 | |
| SCHEMBL28045093 | 0.82 | LTA4H (0.52) | LTA4HADRB1PARP1 | |
| SCHEMBL4979175 | 0.82 | LTA4H (0.52) | LTA4HADRB1PARP1 | |
| SCHEMBL3491740 | 0.81 | LTA4H (0.46) | LTA4HADRB1 | |
| SCHEMBL3493135 | 0.80 | LTA4H (0.43) | LTA4HADRB1PARP1 | |
| SCHEMBL4974701 | 0.79 | LTA4H (0.40) | LTA4HADRB1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |