Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | PGF | P49763 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744717 | 0.76 | AR (0.52) | CYP19A1CYP3A4ARESR2ESR1 | |
| SCHEMBL7048656 | 0.74 | CYP19A1 (0.60) | CYP19A1CYP3A4ARESR2ESR1 | |
| SCHEMBL1933778 | 0.74 | CYP19A1 (0.60) | CYP19A1CYP3A4ARESR2ESR1 | |
| SCHEMBL10365101 | 0.73 | CYP19A1 (0.53) | CYP19A1CYP3A4ARESR2ESR1 | |
| SCHEMBL30362997 | 0.73 | MEN1 (0.48) | PLA2G10PLA2G2APLA2G5ESR2ESR1 | |
| SCHEMBL25567835 | 0.71 | CYP3A4 (0.50) | CYP19A1CYP3A4ARESR2ESR1 | |
| SCHEMBL28019044 | 0.70 | CYP19A1 (0.53) | CYP19A1ARESR2ESR1MAOA | |
| SCHEMBL27898183 | 0.70 | CYP19A1 (0.53) | CYP19A1CYP3A4ARESR2ESR1 | |
| SCHEMBL4972000 | 0.69 | CYP19A1 (0.54) | CYP19A1 | |
| SCHEMBL4364359 | 0.68 | ESR2 (0.53) | CYP19A1CYP3A4ARESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809618-A4 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | NOVOGEN RES PTY LTD (AU) | 2008-11-19 | — | — | EP | disclosed |
| EP-1809618-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | Novogen Research Pty Ltd (AU) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006032086-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | NOVOGEN RESEARCH PTY LTD (AU) | 2006-03-30 | — | — | WO | disclosed |